Title | Structural and surface properties of fibrous membranes for purification and chromatographic separation of biomacromolecules |
Area | Engineering sciences and technologies: Textile and leather |
Presentation illustration | ![]() ![]() ![]() ![]() |
Duration | 1. 7. 2019 – 30. 6. 2022 |
Funding | 300.000 EUR (ARRS) |
Project head | Prof. Dr. Vanja Kokol https://cris.cobiss.net/ecris/si/sl/researcher/8756 |
Participating organizations | BIA Separations L.t.d. Separations technology company https://www.biaseparations.com https://cris.cobiss.net/ecris/si/en/organization/2479 Univerist yof Ljubljana, Biotechnical faculty https://www.bf.uni-lj.si/en/organisation/biology/ IJS, Department of surafce engineering https://f4.ijs.si |
Objectives | In this project we aim to investigate the preparation/manufacturing process for developing of novel low-cost and high-flow fiber-based filters and ion-exchange membranes, which may act as a complementary method to the existing polymeric-based filters or expensive chromatographic monolithic cartridge-based systems, to enable: i) high and sterile bacteria filtration retention, ii) good gDNA and endotoxin removal, and iii) chromatographic purification/separations of proteins, with high performance and economic feasibility. The membranes will be prepared by merging existing textile, paper and composite technologies, optionally in a combination with advanced plasma processing to further chemically modify or functionalize the fibers surface with specific ligand, and thus to tailor/increase the membrane surface area and mass transfer properties with good binding capacity, supporting efficient biomolecules purification, separation and recovery. |
Specific phases and stage of realization |
Developing / manufacturing, characterizing, and testing novel fiber-based:
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Bibliographic references |
Scientific conference contributions KOKOL, Vanja. Nanocellulose-based antimicrobial microparticles as an alternative to toxic nano-biocides. In: International Conference on Cellulose Fibres 2022 : 2 – 3 February 2022, hybrid event, Cologne (Germany). 2022. 1 p. https://cellulose-fibres.eu/poster-session/ KOKOL, Vanja, VIVOD, Vera, SIMČIČ, Tina, ČERNIGOJ, Urh. Characterisation of membranes prepared from carboxymethyl cellulose and cellulose nanofibrils and their applicability for biochromatography. In: Abstract book. 8th Monolith Summer School & Symposium, June 15th-20th 2018, Portoroz, Slovenija. p 46. |